Interference of daratumumab with compatibility testing in blood bank

Interference of daratumumab with pretransfusion testing, mimicking a high-titer, low avidity like antibody

Daratumumab is a monoclonal immunoglobulin against CD38 and has been approved for treating patients with refractory multiple myeloma. The presence of daratumumab in the sera can interfere with pretransfusion testing due to the weakly expression of CD38 on red cells. The reactivity could be mistaken as autoantibody (if autocontrol is positive) or alloantibody (if autocontrol is negative). We pre...

comparison of blood flow velocity changes in posterior cerebral artery measured with transcranial doppler sonography in migraineurs with visual aura and normal persons after photostimulation

چکیده ندارد.

RETICULOCYTE INTERFERENCE WITH LYMPHOCYTE SEPARATION IN BLOOD OF PATIENTS WITH KALA-AZAR

Interference of intravenous vitamin C with blood glucose testing.

Self-monitoring of blood glucose (SMBG) is an integral component in the management of diabetes. However, it is important to understand the limitations of SMBG due to presence of interfering substances (1). We present a patient with diabetes and malignancy, who had falsely elevated blood glucose readings following administration of intravenous ascorbic acid (AA). A 56-year-old woman with type 1 ...

Role of daratumumab in transfusion medicine: a must know entity

Drug interference in serological assays is a well-known phenomenon. Therapeutic monoclonal antibodies (MoAbs) have been successful in treating a variety of malignancies. Some of these MoAbs interfere in day-to-day laboratory tests. Recently, a novel targeted immunotherapy, daratumumab (MoAb against CD38 antigen) was approved for treating advanced stage multiple myeloma (MM).1 Herein, we describ...